Novel Treatment Approach Shrinks Ovarian Tumors in Mice

Researchers have developed a new approach for treating tumors that express mutant versions of the p53 protein, which are present in more than half of all cancers. The approach, the research team believes, could be especially beneficial in women with an aggressive and common subtype of ovarian cancer called high-grade serous.

Approximately 80 percent of ovarian cancers are the high-grade serous subtype, and nearly all tumors of this subtype have mutant forms of p53. Patients with this subtype usually aren’t diagnosed until the cancer is advanced, so long-term survival rates are low, with fewer than half of women alive 5 years after diagnosis.

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